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Another study by Slotkoff (1983) in which hydrochlorothiazide (100 mg) was administered to 74 patients with edema for 12 weeks reported an average weight loss of 5.51 lbs. to 5.95 lbs. – over a 12-week period. In this study, it was noted that a majority of the weight loss and edema reduction were observed within the first week of treatment.
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